Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria

The low efficacy of current conventional treatments for bacterial infections increases mortality rates worldwide. To alleviate this global health problem, we propose drug-free enzyme-based nanomotors the treatment urinary-tract infections. We develop consisting mesoporous silica nanoparticles (MSNPs) that were functionalized with either urease (U-MSNPs), lysozyme (L-MSNPs), or and (M-MSNPs), use them against nonpathogenic planktonic Escherichia coli. U-MSNPs exhibited highest bactericidal activity due to biocatalysis urea into NaHCO3 NH3, which also propels U-MSNPs. In addition, in concentrations above 200 μg/mL capable successfully reducing 60% biofilm biomass a uropathogenic E. coli strain. This study thus provides proof-of-concept, demonstrating are fighting infectious diseases. approach could potentially be extended other kinds diseases by selecting appropriate biomolecules.